PhyscoSens

PhycoSens

The incredible properties of phycocyanin

Phycocyanin is a blue pigment that is only found in certain algae, specifically in cyanobacteria, including the Spirulina family.
Phycocyanin is the main pigment in the microalgae Spirulina platensis. It is the only natural food approved as a culinary blue dye in Europe.
Cyanobacteria are bacteria capable of performing photosynthesis, which releases oxygen (like plants do).
Cyanobacteria can be found in virtually any environment where there is light, water, carbon dioxide and minerals.
They can be found in environments that are ‘extreme’ like the hot thermal springs (up to 70 ° C), the hypersalted water, and polar environments.

How do the Cyanobacteria use the light?

Cyanobacteria have pigments capable of capturing a lot of photons in a wide wavelength spectrum. They have not only oa lot of chlorophyll and carotenoids, like algae and plants, but they also have special pigments called ‘phycobiliproteins’ that are capable of capturing the light in
the wavelengths, where the chlorophyll is not effective in capturing photons.

The solid line in the above picture shows the areas of the spectrum, where chlorophyll is capable of capturing the energy of the photons. The dotted line shows the efficiency of photosynthesis. There is a region from 480 to 650 nm, where the chlorophyll does not absorb photons and where the photosynthetic efficiency with this chlorophyll-pigment is very low. This is where the phycobiliproteins come in and take over ; they include two pigments: phycoerythrin (absorption between 490 and 570 nm) and phycocyanin (absorption between 610 and 655 nm).

Phycocyanin captures light energy, which is then transformed inside the plant cell plant into biochemical energy. It is probably this ability to capture photons that explain some of
its remarkable properties.

 

Phycocyanine

 

Manufacturing phycocyanin:
a critical and exclusive process

A major factor is the raw material for the phycocyanine’s extraction is only fresh spirulina (not powder because the process of drying always destroys some active ingredients).
Spirulina is cultivated in a photobioreactor (in controlled conditions: pH, light, temperature, microbiological safety ..). Spirulina is then concentrated using a special cultivation method to get the correct optical density required for the extraction of phycocyanin.
This method allows to obtain the currently most highly concentrated phycocyanin (3 g / liter). Phycocyanin can be found in algae food supplements presented in dried form (spirulina tablets, AFA Klamath or chlorella) but the native form of phycocyanin (soluble fluid extract) shows a hundred times higher therapeutic results than that achieved with dehydrated forms. « Phycosens » not only contains the highly concentrated Phycocyanin but also a portion of the water-soluble fraction of the Spirulina as well: proteins, amino acids, enzymes, polysaccharides, water-soluble vitamins, mineral salts.

The many properties
of phycocyanin and indications

Phycocyanin is a therapeutic gem, it is the blue gold spirulina. This is a very effective solution to many common diseases, but also to serious diseases such as leukemia and cancer. To give an order of magnitude, phycocyanin is 6000 to 7000 times more active than Spirulina itself and 20 times more potent than vitamin C.

1 Action on the production of stem cells from the bone marrow.

Several studies have demonstrated the ability of phycocyanin to promote differentiation of stem cells in the bone marrow. Phycocyanin increases the production of the hormone erythropoietin (EPO), which promotes the production of red blood cells. It also promotes the production of white blood cells and platelets.
Indications: anemia, fatigue, recovery after intensive physical effort.

2 Action on leukemia

Phycocyanin helps to stop the developing phase of the cells as well as the production of the necessary substances needed for the division of cells, that are responsible for chronic myelogenous leukemia. Phycocyanin brings great hope for chronic or acute leukemia. It is a must for this type of pathology, through its inhibitory effect on the growth of human leukemia K562 cells.
Indications: Chronic or acute myeloid leukemia.

3 Action on the immune system

The Phycocyanin acts as an immunomodulator:
• Phycocyanin stimulates very effectively the thymus functions that plays an important role in cellular immunity. NK cells (Natural Killer) cells are related to T cells that destroy virus-infected cells and cancer cells.
• Phycocyanin diminishes or eradicates allergic inflammation by decreasing excess IG E
Indications: recurrent infections, viral infections, cancer, allergic rhinitis.

4 Antioxidant and radical-scavenging action

Free radicals cause chain reactions that alter cell membrane phospholipids and degrade the connective tissue. To counter this oxidation phenomenon of the body, our body produces antioxidants such as superoxide dismutase (SOD), catalase, glutathione peroxidase but these productions decreases with age. There are also antioxidants that one draws from the diet such as vitamins C and E. Studies show that phycocyanin has great antioxidant activity:
• 70 times higher than SOD,
• 16 times greater than vitamin E,
• 20 times greater than vitamin C.
Indications: prevention of aging, neurodegenerative diseases (Alzheimer, Parkinson)

5 Antiviral Action

The Phycocyanin has potent antiviral activity. Phycocyanin and the other ingredients associated with spirulina (contained in Phycosens), enable the inhibition of the replication of the AIDS virus (HIV).
Phycocyanin also inhibits other viruses such as those from measles, influenza, mumps, herpes simplex, cytomegalovirus.
Indications: acute or chronic viral infections.

6 Anticancer Action

Phycocyanin inhibits the breaks in the DNA threads. It enhances the enzymatic activity of the cell’s nucleus and DNA repair synthesis.

7 Action on the liver

Phycocyanin is very beneficial to the functioning of the liver because it is detoxifying and is hepatoprotective. It very effectively reduces the hepatotoxicity caused by chemicals such as pesticides and it is advised to give Phycocyanin systematically to patients on chemotherapy. As phycocyanin is capable of binding with bile acids (as a bilprotéine bilirubin), it increases the fecal excretion of cholesterol and bile acids.
Indications: liver disease including cirrhosis, fouling of the body (heavy metals), chemotherapy, cholesterol.

8 Action on Diabetes

Some studies have shown that phycocyanin reduces the rate of blood sugar in diabetes type 2 It also helps to treat diabetic complications such as diabetic retinopathy.
Indications: Type 2 diabetes and its complications.

9 Action on kidneys

Kidney stones usually form by the precipitation of crystals of calcium oxalate. Phycocyanin causes biochemical changes in the formation of oxalate, thereby preventing the occurrence of kidney stones. It also protects the kidneys against mercury toxicity and drugs.
Indications: kidney stones, renal colic, kidney protection (mercury, drugs).

10 Action on thyroid

Phycocyanin is indicated in cases of hypothyroidism because it regulates the thyroid and promotes thyroid hormones production. In case of Hashimoto’s thyroiditis, its anti-inflammatory and immune modulating effect (in combination with Moducare) will also be of of great help.
Indications:hypothyroidism, Hashimoto.

11 Action on Heavy Metals

Heavy metals are deposited in the middle or heart of the tissues and disrupt cell functions, especially in liver, kidney and the brain. Polysaccharides of spirulina and phycocyanin have the ability to chelate these toxic elements and eliminate them from the body.

12 Selective anti-inflammatory Action

Prostaglandins are hormones that are the mediators of the inflammatory reaction, which are produced by the action of cydooxygenases enzymes (COX) on the fatty acids (arachidonic acid) from the cell membrane.

 

• COX-1 produces prostaglandins PGE1 protecting the gastrointestinal mucosa, thins the blood and prevents inflammation;
• COX-2 produces PGE2 prostaglandins that cause inflammation.

Phycocyanin selectively inhibits COX2 and thus blocks the production of bad prostaglandins (PGE2), which are responsible for pain and inflammation, while respecting the production of good prostaglandins (PGE1). Therefore phycocyanin is an anti-inflammatory product, with no side effects on the stomach or cardiovascular health.

Indications:inflammation, rheumatism.

13 Cardiovascular Action

Phycocyanin contributes to good cardiovascular health and prevents thrombosis (heart attack, stroke) through several synergies:
• It has anti-cholesterol activity
• It has an anti-coagulating action,
• Its powerful antioxidant activity hinder arterial lesions that lead to atherosclerosis

Indications: prevention of cardiovascular problems.

Scientific Publications

1 Action on the production of stem cells from the bone marrow.

Effects of polysaccharide and phycocyanin from spirulina on peripheral blood and hematopoietic system bone marrow in mice. April 1994. Pub. In Proc. of Second Asia Pacific Conf. On Algal Biotech. Univ of Malaysia. P.58. China

The Phycocyanin is an antioxidant Protecteur Human erythrocytes against lysis by peroxyl radicals. Department of Pharmacology, National Center for Scientific Research, PO Box 6412. Havana City. Cuba. Department of Pharmacology, National Center for Scientific Research, PO Box 6412. Havana City. Cuba

2 Action on leukemia

Inhibitory Effects of phycocyanin extracted from Spirulina platensis after the growth of human leukemia K562 cells. Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India

3 Action on the immune system

Activation of the immune system by Spirulina: increase of interferon production and cytotoxicity of NK cells by oral administration of a hot water extract of Spirulina platensis. Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan

4 Antioxidant and radical-scavenging action

Antioxidant and anti-inflammatory properties of c-phycocyanin extracted from blue-green algae.
Romay C, Armesto J, Remirez D, Gonzalez R, Ledon L, Garcia I. Inflamm Res.1998 ; 47 : 36-41.

C-phycocyanin : a biliprotein with antioxdant, anti-inflammatory and neuroprotective effects.
Romay C, Gonzalez R, Ledon N, Remirez D, Rimbau V. Curr Protein Pept
Sci. 2003 Jun;4(3):207-16.

5 Antiviral Action

Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis).
Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute, and Harvar—d Medical School, Boston, Massachusetts 02115, USA.

bis Calcium Spirulan, an inhibitor of virus replication shell, taken from a blue-green alga, Spirulina platensis. Faculty of Pharmaceutical Sciences and School of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan

6. Anticancer Action

Anti-cancer effects of polysaccharide and phycocyanin from porphyra yezoensis. Lu-Xi Zhang*, Chun-Er Cai*, Ting-Ting Guo*,… Journal of Marine Science and Technology, Vol. 19, No. 4, pp. 377-382 (2011)

Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS. Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.


7. Action on the liver

Protective effect of C-phycocyanin against carbon tetrachloride- induced hepatocyte damage in vitro and in-vivo. Ou Y, Zheng S, Lin L, Jiang Q, Yang X Chem Biol Interact. 2010 Apr 29;185(2):94-100. Epub 2010 Mar 12

8. Action on diabetes

A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Lee, EH, Park, J-E, Choi, Y-J, Huh, K-B and Kim, W-Y. Nutrition Research and Practice 2(4):295-300-2008

9. Action on kidneys

Antioxidant property of C-phycocyanin protects the renal cell against oxalate-induced injury and may be a nephroprotective agent. Dr. AL Mudalia – Clin Chim Acta. 2004 Oct; 348(1-2):199-205.

10. Action on thyroid

Investigation on the role of Spirulina platensis in improving the behavioural changes, thyroid dysfunction and oxidative stress in offsprings of pregnant rats exposed to fluoride. Banji D, Banji OJ, Pratusha NG, Annamalai AR. Food Chem. 2013 Sep 1;140(1-2):321-31. doi: 10.1016/j.foodchem.2013.02.076. Epub 2013 Feb 28.

11. Action on heavy metals

Interacion of Heavy Metal Ions with C-Phycocyanin: Binding
Isotherms and Cooperative Effects. Eteri Gelagutashvili - E.L. 6
Andronikashvili Institute of Physics, 6 Tamarashvili str., Tbilisi, 0177,
Georgia

12. Selective anti-inflammatory Action

Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis. Reddy CM, Bhat VB, Kiranmai G, Reddy MN, Reddanna P, Madyastha KM. Biochem Biophys Res Commun.
2000 Nov ; 277 (3) : 599-603.

13. Cardio-vasculary Action

Mechanisms involved in the antiplatelet effect of C-phycocyanin. Hui-Fen Chiu1, Shih-Ping Yang2, Yu-Ling Kuo3, Yuan-Shu Lai4 and Tz- Chong Chou – British Journal of Nutrition (2006), 95, 435–440

Phycobiliprotein C-phycocyanin from Spirulina platensis is responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters. Jérome Riss, Kelly Décordé, Thibault Sutra, Martine Delage, Jean-Claude Baccou, Nicolas Jouy, Jean-Pierre Brune, Henri Oréal, Jean-Paul Cristol, Jean-Max Rouanet - J Agric Food Chem 2007 Sep 16;55(19):7962-7. Epub 2007 Aug 16.

A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats. Nagaoka S, Shimizu K, Kaneko H, Shibayama F, Morikawa K, et al (2005) - J Nutr 135 (10) 2425-2430.

 

 

 

Directions for use of Phycosens:

Preventive:

1 vial daily in the morning on an empty stomach.
Keep product under the tongue at least 1 minute before swallowing.

Curative:

Vials per day (morning and evening) Keep product cool and protected from light!

Packaging:

Single vial dose (10 ml), box of ten units.